The meeting also aims to highlight the latest research trends by featuring talks by many leading italian scientists, including Luigi Naldini, Stefano Volinia, Maria Pia Longhese, Claudio Brancolini, Giovanni Blandino, Alberto Gulino, Francesca Granucci, Claudio Schneider, Antonello Pietrangelo, Francesco Cecconi, Michele De Luca, Luca Scorrano and Enrico Avvedimento.

The meeting offers an exciting opportunity for young researchers and PhD students for scientific exchange and to present their own work with posters or as selected platform presentations. At the end of the meeting, the "Chiara D'Onofrio Giovani" prize (2000 euros) will be awarded to the best oral presentation.

Also, as the meeting ends on Saturday morning, you may take the opportunity to enjoy Padova and the sites where experimental scientific method was born.

We very much look forward to welcome you here,

Stefano Piccolo

Giannino Del Sal

Programme

Thursday, 3 June

Session I NON CODING RNA - Chair: Valerio Orlando

• 14.45-15.30 Keynote Lecture: Ruggero De Maria - From biomarkers to biotherapeutics: the new frontier of microRNAs in cancer
• 15.30-15.55 Luigi Naldini - Exploiting and antagonizing microRNA regulation in gene therapy
• 15.55-16.15 Coffee Break
• 16.15-17.25 Poster Session I
• 17.25-17.50 Stefano Volinia - Reprogramming of miRNA networks in cancer and leukemia
• 17.50-18.15 Claudio Schneider - The stromal microenviroment, its precursor cells and role in serous ovarian carcinoma
• 18.15-18.30 Silvia Barabino - Genotoxic stress modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2
• 18.30-18.45 Maria Cristina Onorati - Functional interaction between chromatin remodelers and non-coding RNA’s

Friday, 4 June

Session II GENOMIC STABILITY, PLASTICITY AND DIFFERENTIATION - Chair: Giulia Piaggio

• 9.00-9.45 Keynote Lecture: Marco Foiani - Mechanisms controlling genome integrity
• 9.45-10.10 Maria Pia Longhese - Regulating processing of accidental and specialized chromosome ends
• 10.10-10.35 Enrico Avvedimento - Transcription driven by oxidation: chromatin loops
• 10.35-11.00 Claudio Brancolini - Isopeptidases in the control of apoptosis: exploring new therapeutic potentials
• 11.00-11.20 Coffee Break
• 11.20-11.35 Chiara Lanzuolo - Maintenance of PcG mediated epigenetic signatures through S phase in Drosophila melanogaster
• 11.35-11.50 Elena Longobardi - Expression and function of the TALE proteins in mouse mammary gland stem cell and progenitors
• 11.50-12.05 Simona Pilotto - Design and development of new inhibitors of the histone demethylases LSD1 and LSD2

Session III SIGNALING PATHWAYS - Chair: Giannino Del Sal

• 12.05-12.50 Keynote Lecture: Pier Paolo Di Fiore - Decoding the endocytic matrix
• 12.50-13.50 Lunch
• 13.50-14.15 Alberto Gulino - Regulation of Hedgehog/Gli function in neural stem/progenitor and medulloblastoma cells
• 14.15-14.40 Francesca Granucci - CD14 regulates the dendritic cell life cycle through NFAT activation following LPS encounter
• 14.40-14.55 Barbara Stecca - Hedgehog-Gli signaling controls neural stem cell and tumor cell numbers
• 14.55-15.10 Fiamma Mantovani - BRD7 is a candidate tumor suppressor gene required for p53 function
• 15.10-15.25 Fabiana Aceto - Mechanism of retinoic acid-induced transcription: epigenetic changes, DNA oxidation and formation of chromatin loops
• 15.25-16.35 Poster Session II
• 16.35-16.55 Coffee break

Session IV SIGNALING PATHWAYS AS THERAPEUTIC TARGETS - Chair: Francesco Cecconi

• 16.55-17.40 Keynote Lecture: Alberto Bardelli - Cancer mutations and targeted therapies in cells, mice and patients
• 17.40-18.05 Giovanni Blandino - Therapeutic targets in breast cancer
• 18.05-18.30 Antonello Pietrangelo -Targeting the hepcidin signalling pathway to cure human iron disorders
• 18.30-18.45 Anna Montesano - Resveratrol promotes myogenesis and hypertrophy in murine myoblasts
• 18.45-19.00 Alessio Valletti - Identification of tumor-associated alternative splicing events in human cancer through EST-based computational prediction and experimental validation
• 19.00-19.15 Simona Pedrotti - The RNA-binding protein Sam68 regulates SMN2 exon 7 alternative splicing in spinal muscular atrophy
• 20.30 Social dinner

Saturday, 5 June

Session V CELL BIOLOGY & CELL THERAPY - Chair: Enrico Avvedimento

• 9.00-9.45 Keynote Lecture: Rosario Rizzuto - Mitochondria, calcium, and cell death
• 9.45-10.10 Francesco Cecconi - Autophagy regulation in cell death and survival
• 10.10-10.35 Michele De Luca - Epithelial stem cells and regenerative medicine
• 10.35-10.55 Coffee Break
• 10.55-11.20 Luca Scorrano - Size matters: mitochondrial elongation is a conserved and protective step of autophagy
• 11.20-11.35 Paolo Grumati - Autophagy is defective in dystrophic muscle and its reactivation rescues myofiber degeneration
• 11.35-11.50 Marco Tripodi - Epithelial differentiation and liver zonation of hepatocyte imply coordinate activation and repression of HNF4α target genes
• 11.50-12.55 Chiara D'Onofrio "Giovani" Award
• 12.55 Final remarks

ATTENTION

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